Learning to do things that require two hands with one, because the other is holding a beer. TFM.

This is funny because fraternity men are known to enjoy consuming mass quantities of beer, to the point where they are seldom seen without one in hand. However, maintaining this consistency of alcoholic possession is likely to impede in the completion of many mundane tasks which require more than one hand to accomplish with ease. The poster is implying that his love of beer is so extreme that he is willing to learn the significantly more difficult one-handed method of accomplishing these tasks rather than set his beer down momentarily to use the traditional two-handed method, which is what one would normally expect a person to do.